一、 个人简介
高玉祺，博士，山东第一医科大学放射学院骨干人才，校聘副教授，放射与防护教研室教师。2018年于山东大学获得医学博士学位，后进入中山大学从事博士后研究。2021年12月入职我校，主要从事化学生物学领域相关研究，并将相关结果整理为多篇论文。以第一作者/通讯作者身份发表文章7篇，其中SCI一区3篇，二区3篇，三区1篇；参与申请中国专利1项，已授权；已主持科研项目2项。
二、 研究方向
1、利用光学探针实现对疾病相关重要标志物的可视化分析。了解被分析物在疾病发生发展过程中的作用，并进一步实现对相关疾病的早期诊断及预后评价。
2、基于多组学分析发现小分子作用靶点并验证其调控机制。基于生物信息学分析，确定活性小分子作用过程中的关键差异分子，发现其作用靶点，阐释其调控机制。
三、 承担的主要科研项目
1、中国博士后科学基金会，博士后面上项目，2019M663325，新型抗肺动脉高压PDE10荧光探针的设计及分子机制研究，2019-01至2021-12，8万元，结题，主持。
2、中山大学青年教师培育项目，19ykpy126，特异性识别PDE10的功能分子发现及其抗肺动脉高压活性和可视化分析研究，2019-01至2021-12，15万元，结题，主持。
四、 发表的主要科研论文
1. Gao Y, Lin Y, Liu T, Chen H, Yang X, Tian C, Du L, Li M (*). Bioluminescent probe for tumor hypoxia detection via CYP450 Reductase in Living Animals. Analytical Chemistry 2017, 89(22): 12488-12493.
2. Gao Y, Lin Y, Liu T, Zhang X, Xu F, Liu P, Du L, Li M (*). A specific and selective chemiluminescent probe for Pd2+ detection. Chinese Chemical Letters 2019, 30(1): 63-66.
3. Gao Y, Huang J, Zhou Q, Liu R, Zhang S, Zhang C, Huang Y-Y, Li Z, Huang L, Wu D, Wu Y, Xiao L, Lei Guo L (*), Luo H-B (*). Discovery of a highly specific fluorescent probe targeting the active site for detecting lysosomal PDE10A in living cells. ACS Chemical Biology 2021, 16(5): 857-863.
4. Qiu M (#), Wu D (#), Huang Y-Y, Huang Y, Zhou Q, Tian Y, Guo L, Gao Y (*), Luo H-B (*). Discovery of catalytic-site-fluorescent probes for tracing phosphodiesterase 5 in living cells. RSC Advances 2021, 16(5): 857-863.
5. Xue H (#), Lu J (#), Yan H, Huang J, Luo H-B, Wong M S, Gao Y (*), Zhang X (*), Guo L (*). γ-Glutamyl transpeptidase–activated indole-quinolinium based cyanine as a fluorescence turn-on nucleolus-targeting probe for cancer cell detection and inhibition. Talanta 2021, 237(2022): 122898-122906.
6. Sun Y (#), Gao Y (#), Tang C, Dong G, Zhao P, Peng D, Wang T, Du L, Li M (*). Multiple rapid-responsive probes towards hypochlorite detection based on dioxetane luminophore derivatives. Journal of Pharmaceutical Analysis 2022, 12, 446-452.
7. Zhang J (#), Gao Y (#), Zhang Z, Zhao J, Jia W, Xia C, Wang F (*), Liu T (*). Multi-therapies Based on PARP inhibition: potential therapeutic approaches for cancer treatment. Journal of Medicinal Chemistry 2022, 65(24):16099-16127.
8. Yuan M (#), Ma X (#), Jiang T, Zhang C, Chen H, Gao Y, Yang X, Du L, Li M (*). A novel coelenterate luciferin-based luminescent probe for selective and sensitive detection of thiophenols. Organic & Biomolecular Chemistry 2016, 14(43): 10267-10274.
9. Liu T, Gao Y, Zhang X, Wan Y, Du L, Fang H, Li M (*). Discovery of a turn-on fluorescent probe for myeloid cell leukemia-1 protein. Analytical Chemistry 2017, 89(21): 11173-11177.
10. Liu J, Tian C, Jiang T, Gao Y, Zhou Y, Li M, Du L (*). Discovery of the first environment-sensitive fluorescent probe for GPR120 (FFA4) imaging. ACS Medicinal Chemistry Letters 2017, 8(4): 428-432.
11. Lin Y, Gao Y, Ma Z, Li Z, Tang C, Qin X, Zhang Z, Wang G, Du L, Li M (*). Bioluminescent probe for detection of starvation-induced pantetheinase upregulation. Analytical Chemistry 2018, 90(15): 9545-9550.
12. Lin Y, Gao Y, Ma Z, Jiang T, Zhou X, Li Z, Qin X, Huang Y, Du L, Li M (*). Bioluminescence probe for gamma-glutamyl transpeptidase detection in vivo. Bioorganic and Medicinal Chemistry 2018, 26(1): 134-140.
13. Yuan M (#), Ma X (#), Jiang T, Gao Y, Cui Y, Zhang C, Yang X, Huang Y, Du L, Yampolsky I, Li M (*). Prolonged bioluminescence imaging in living cells and mice using novel pro-substrates for Renilla luciferase. Organic & Biomolecular Chemistry 2017, 15(48): 10238-10244.
14. Tang C, Gao Y, Liu T, Lin Y, Zhang X, Zhang C, Li X, Zhang T, Du L, Li M (*). Bioluminescent probe for detecting endogenous hypochlorite in living mice. Organic & Biomolecular Chemistry 2018, 16(4): 645-651.
15. Zhang C, Yuan M, Han G, Gao Y, Tang C, Li X, Du L, Li M (*). Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo. RSC Advances 2018, 8(35): 19596-19599.
16. Lin Y, Ma Z, Li Z, Gao Y, Qin X, Zhang Z, Wang G, Du L, Li M (*). Bioluminescent probe for monitoring endogenous fibroblast activation protein-alpha. Analytical Chemistry 2019, 91(23): 14873-14878.
17. Zhang X, Liu T, Wang B, Gao Y, Liu P, Li M, Du L (*). Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel. MedChemComm 2019, 10(4): 513-516.
18. Liang J (#), Huang Y-Y (#), Zhou Q (#), Gao Y, Li Z, Wu D, Yu S, Guo L, Chen Z, Huang L, Liang SH, He X (*), Wu R (*), Luo H-B (*). Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia. Journal of Medicinal Chemistry 2020, 63(6): 3370-3380.
19. Yang Y (#), Zhang S (#), Zhou Q (#), Zhang C, Gao Y, Wang H, Li Z, Wu D, Wu Y, Huang Y-Y (*), Guo L (*), Luo H-B (*). Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension. Acta Pharmaceutica Sinica B 2020, 10(12): 2339-2347.
20. Yu Y-F (#), Zhang C (#), Huang Y-Y (#), Zhang S, Zhou Q, Li X, Lai Z, Li Z, Gao Y, Wu Y, Guo L (*), Wu D (*), Luo H-B (*). Discovery and optimization of chromone derivatives as novel selective phosphodiesterase 10 inhibitors. ACS Chemical Neuroscience 2020, 11(7): 1058-1071.
21. Xu C (#), Xiao Z (#), Wang J, Lai H, Zhang T, Guan Z, Xia M, Chen M, Ren L, He Y, Gao Y, Zhao C (*). Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer. Journal of Medicinal Chemistry 2021, 64(18): 13312-13326.
22. Zhang Z, Lin Y, Li Z, Dong G, Gao Y, Ma S, Li J, Du L, Li M (*). Bright chemiluminescent dioxetane probes for the detection of gaseous transmitter H2S. Bioorganic & Medicinal Chemistry Letters 2021, 46: 128148.
五、 授权的主要专利
1. 一类苯并咪唑类衍生物及其制备方法和应用；CN202010260337.1，发明专利，中国，国家知识产权，授权日期：2021-10-15，个人位次:4。
六、 联系方式
电子邮箱：gaoyuqi@sdfmu.edu.cn
